Project 16: Multimodal imaging for upright posture

Enrollment: ETH Zurich

Host institution: Paul Scherrer Institute
Planned secondments
  1. TheraPanacea (France)
  2. ASG Superconductors (Italy)
  3. GSI Helmholtzzentrum für Schwerionenforschung (Germany)
Supervisor
Co-Supervisor
Tony Lomax
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Project description

Background and Motivation: 

Not all treatment centres will have access to upright imaging modalities, so there is a critical need for alternative approaches. Developing a versatile image guidance workflow, empowered by robust deformable image registration and associated algorithms for generating supine-to-upright image transformations, will be vital to ensure accurate treatment planning in centres with limited resources.

Goal: 

A comprehensive multi-modality image-guided workflow, establishing treatment planning, robustness, and margin guidelines based on the gathered upright imaging data and numerical phantom

Tasks:

  • Develop a versatile image analysis framework (including deformable registration, image synthesis and reconstruction) for multi-modality multi-posture images used for upright RT
  • Generate anthropomorphic numerical (4D) phantoms for simulating upright anatomy and its possible variations
  • Design and in-vivo validate an efficient multi-modal image guidance workflow for upright RT
  • 3 months secondment @Therapanacea (synthetic image)
  • 3 weeks of research visiting @ASG (4DMR imaging)
  • 3 weeks of research visiting @DKFZ (physical phantom design)
  • Close collaboration with DC17 and PhDs students in PSI-CPT
  • Teaching assistant for ETHz Physics department
  • Presentation of research in the form of peer-reviewed publications, reports and oral presentations in workshops, symposiums and conferences
  • Participation in Consortium training activities and secondment projects

RonjaStern

Ronja Stern

Paul Scherrer Institute

Project 16, ‘Multimodal Imaging for Upright Posture’, is carried out by Ronja Stern at the Paul Scherrer Institute (PSI) in Switzerland. She began her PhD in September 2025, under the supervision of Dr Ye Zhang, a tenured scientist at the Centre for Proton Therapy (CPT) at PSI.

Having obtained a Bachelor’s degree in Computer Science (University of Bern) and a Master’s degree in IT & Cognition (University of Copenhagen), Ronja’s goal is to develop AI-driven methods for upright proton therapy.

She is a disciplined, dedicated and curious researcher who is eager to learn and understand how things work, from the highest conceptual level to technical implementation.

Drawing on her background in computer science, she is developing AI-driven methods that combine multimodal imaging, motion modelling, and treatment adaptation.

The aim is to create more accurate and efficient patient-specific workflows, from image synthesis and registration to dose prediction. In doing so, she is bridging the gap between her theoretical knowledge and real-world clinical applications that could one day benefit patients.

She is eager to gain a deeper understanding of the field, establish a professional network across Europe, and collaborate with experts from various institutions.

In her free time, she enjoys playing sports such as badminton, skiing and cycling.

Additional:

Ronja Stern | LinkedIn

Paul Scherrer Institute

The Paul Scherrer Institute (PSI) is the largest research institute in Switzerland, and the Center for Proton Therapy (CPT) is the only radiotherapy department in the country offering this unique, highly precise proton radiotherapy treatment. The PSI-CPT has been a long-lasting global leader and pioneer in developing and clinically implementing pencil beam scanning and Intensity Modulated Proton Therapy. As a fully operational proton therapy center, PSI-CPT boasts a comprehensive suite of related equipment, including a proprietary pencil beam scanning proton therapy system with three gantries ...