Project 11: Design of isocentric MRI guided upright particle therapy

Enrollment: Technische Universität Dresden

Host institution: Helmholtz-Zentrum Dresden-Rossendorf
Planned secondments

1. ASG Superconductors S.p.A. (Italy)
2. Loughborough University, Leo Cancer Care (UK)
3. Paul Scherrer Institute (Switzerland)

Application deadline
2025-01-15
Supervisor
Co-Supervisor
Bradley Oborn
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Project description

Magnetic resonance imaging (MRI) has the capability to provide unrivalled soft-tissue contrast images in real-time. However, the development of in-beam MRI for proton therapy has only recently started and not yet reached technical maturity to be introduced into the clinic. Recently, a unique, whole-body in-beam MRI device has been installed at HZDR/OncoRay in Dresden (Germany). By means of the rotating, open-bore magnet, this device offers the possibility to scan and irradiate patients in both recumbent and upright posture. 

 

 

Objective 

The aim of this project is to optimize this in-beam MR scanner for image acquisition and treatment planning studies in upright position, identify potential technical hurdles to be overcome for upright rotational proton therapy, and develop a conceptual design for a future clinical upright MR-integrated proton therapy system. 

  

Tasks 

To understand the technical requirements to enhance the available in-beam MRI system for clinical use. To optimize the image quality for upright patient scanning and to acquire MRI data of patients for treatment planning studies on upright proton therapy using real-time MRI guidance. To perform computer simulation studies to conceptually design an in-beam upright MRI system for rotational proton therapy. 

 

Your profile 

  • Higher education in Physics, Biomedical Engineering, or a related field  
  • Proficiency in spoken and written English 
  • Proven experience in MR imaging and magnetic modelling with finite element methods in COMSOL or Opera simulation software is highly desirable 
  • Excellent problem-solving skills, academic writing skills, and communication skills 
  • Ability to work independently as well as in a team 

 

Application process 

If you find this position interesting and would like to work in an exceptional, international, strongly innovative environment, please send your full application documents, including the filled application form, motivation letter, short CV, list of most important publications with explanation of your own contribution, and information of your earliest possible starting date. If you are applying for more than one UPLIFT PhD position, you may indicate your top 3 preferences in the application form. Please submit your application through the form below until January 15, 2025. If you have questions, feel free to send an email to [email protected].

We anticipate video conference interviews with candidates starting in the third week of February,
for start dates from March 2025. Applications submitted without any of the required documents will not be considered.  

Candidates can be of any nationality but must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before their recruitment date. Applicants should be within the first four years of their research careers and must not have been awarded a doctoral degree. Submitted applications will be evaluated in accordance with the European Code of Conduct for Recruitment. 

 

 

 

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Helmholtz-Zentrum Dresden-Rossendorf

Through cutting-edge research, the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) solves pressing societal and industrial challenges of our time. A strong collaboration between the HZDR, the Faculty of Medicine Carl Gustav Carus and the University Hospital Carl Gustav Carus jointly operates OncoRay center. Cancer patients are treated with proton therapy at the University Proton Therapy Dresden. In the facility’s experiment room, the world’s first in-beam MRI system for proton therapy was developed in 2017. Since then, HZDR / OncoRay is pioneering MRI-integrated proton therapy