Project 16: Multimodal imaging for upright posture

Enrollment: ETH Zurich

Host institution: Paul Scherrer Institute
Planned secondments
  1. RaySearch Laboratories (Sweden)
  2. Centro Nazionale di Adroterapia Oncologica (CNAO) (Italy)
  3. Helmholtz-Zentrum Dresden-Rossendorf (HZDR) (Germany)
Supervisor
Co-Supervisor
Tony Lomax
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Project description

Background and Motivation: 

Not all treatment centres will have access to upright imaging modalities, so there is a critical need for alternative approaches. Developing a versatile image guidance workflow, empowered by robust deformable image registration and associated algorithms for generating supine-to-upright image transformations, will be vital to ensure accurate treatment planning in centres with limited resources.

Goal: 

A comprehensive multi-modality image-guided workflow, establishing treatment planning, robustness, and margin guidelines based on the gathered upright imaging data and numerical phantom

Tasks:

  • Develop a versatile image analysis framework (including deformable registration, image synthesis and reconstruction) for multi-modality multi-posture images used for upright RT
  • Generate anthropomorphic numerical (4D) phantoms for simulating upright anatomy and its possible variations
  • Design and in-vivo validate an efficient multi-modal image guidance workflow for upright RT
  • 3 months secondment @Therapanacea (synthetic image)
  • 3 weeks of research visiting @ASG (4DMR imaging)
  • 3 weeks of research visiting @DKFZ (physical phantom design)
  • Close collaboration with DC17 and PhDs students in PSI-CPT
  • Teaching assistant for ETHz Physics department
  • Presentation of research in the form of peer-reviewed publications, reports and oral presentations in workshops, symposiums and conferences
  • Participation in Consortium training activities and secondment projects

RonjaStern

Ronja Stern

Paul Scherrer Institute

My name is Ronja Stern, I am from Switzerland, where I am currently working on Project 16 ‘Multimodal Imaging for Upright Posture’. I have started my PhD in September 2025 under the supervision of Dr Ye Zhang, a tenured scientist at the Centre for Proton Therapy at the Paul Scherrer Institute (PSI). I obtained a bachelor’s degree in computer science at the University of Bern and a master’s degree in IT & Cognition at the University of Copenhagen.

The reason why I joined this project is my fascinated with bridging the gap between theoretical knowledge and real-world clinical applications. Drawing on my background in computer science, my goal is to develop AI-driven methods that enable more accurate, efficient and patient-specific workflows in radiation therapy. To achieve this, I am particularly interested in physics-informed models, motion modelling and multimodal learning approaches. As part of my project, I plan to work on the generation of synthetic medical images, image registration and dose prediction, with the long-term aim of improving treatment quality and clinical decision-making. With my work I aim to contribute to the foundations of upright radiotherapy workflows. I am eager to deepen my understanding of medical physics, to establish a professional network across Europe, and collaborate with and learn from experts at different institutions.

I consider myself a dedicated, curious person, who enjoys understanding how things work, from the highest conceptual level to technical implementation. Before joining academia, I was a professional badminton player representing Switzerland at multiple international competitions. In my free time, I continue to enjoy doing sports such as badminton, skiing, cycling or disc golf, which I see as the perfect complement to research and academic work.

Ronja Stern | LinkedIn

Paul Scherrer Institute

The Paul Scherrer Institute (PSI) is the largest research institute in Switzerland, and the Center for Proton Therapy (CPT) is the only radiotherapy department in the country offering this unique, highly precise proton radiotherapy treatment. The PSI-CPT has been a long-lasting global leader and pioneer in developing and clinically implementing pencil beam scanning and Intensity Modulated Proton Therapy. As a fully operational proton therapy center, PSI-CPT boasts a comprehensive suite of related equipment, including a proprietary pencil beam scanning proton therapy system with three gantries ...